Target Validation

Gain unmatched insights into compound-induced ubiquitination

NEOsphere Biotechnologies' groundbreaking global ubiquitinomics platform captures ubiquitination events with unprecedented detail, providing a comprehensive understanding of dynamic ubiquitin signaling at a systemic level.

Our advanced processes integrate KGG-remnant profiling with single-shot DIA-MS, ensuring precise assessment of compound-induced ubiquitination and deubiquitination across the proteome through custom neural network-based data processing. Analysis is performed on unmodified cells or tissues without the need for proteasome inhibition or genetic modifications.

This unique technology swiftly and systematically validates potential degrader targets, such as those identified through Deep Proteomic Screening.

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	VALIDATION Confirm ubiquitination of potential degrader targets
	INSIGHTS Map ubiquitination-regulated pathways to reveal cellular degradation processes and disease mechanisms
	DEPTH Profile up to 50,000 ubiquitination sites per sample for unprecedented coverage, sensitivity, and precision
	SPEED High-throughput analysis for rapid target validation in drug optimization cycles
	HIGH RESOLUTION Track target and global ubiquitination over time, from rapid events to later stages