Scientific excellence and technological leadership form the foundation of NEOsphere Biotechnologies’ unique platform and capabilities. Our extensive track record of publications in top-tier scientific journals serves as a testament to this.
/ Steger M, Nishiguchi G, Wu Q, Schwalb B, Shashikadze B, McGowan K, Shi Z, Price J, Mayasundari A, Yang L, Bednarz AH, Machata S, Graef T, Bartoschek D, Demichev V Ohmayer U, Yang J, Daub H and Rankovic Z. Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics. 2024. bioRxiv preprint Article ->
/ Thielert M, Itang EC, Ammar C, Rosenberger FA, Bludau I, Schweizer L, Nordmann TM, Skowronek P, Wahle M, Zheng WF, Zhou XX, Brunner AD, Richter S, Levesque MP, Theis FJ, Steger M, Mann M. Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel. Mol Sys Biol. 2023 Sep 12;19(9):e11503. doi: 10.15252/msb.202211503. Article ->
/ Steger M, Karayel O, Demichev V. Ubiquitinomics: History, methods, and applications in basic research and drug discovery. Proteomics. 2022. Mar 30; e2200074. DOI:10.1002/pmic.202200074. Article ->
/ Steger M, Demichev V, Backman M, Ohmayer U, Ihmor P, Müller S, Ralser M, Daub H. Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale. Nat Commun. 2021. Sep 13;12(1):5399. DOI: 10.1038/s41467-021-25454-1. Article ->
/ Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S. The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway. Nat Immunol. 2021. Apr;22(4):485-496. DOI: 10.1038/s41590-021-00896-3. Article ->
/ Karayel O, Tonelli F, Virreira Winter S, Geyer PE, Fan Y, Sammler EM, Alessi DR, Steger M, Mann M. Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. Mol Cell Proteomics. 2020. 19(9), 1546–1560. DOI: 10.1074/mcp.RA120.002055. Article ->
/ Maier K, Gressel S, Cramer P, Schwalb P. Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms. Genome Research. 2020. 30: 1332-1344 DOI: 10.1101/gr.257857.119. Article ->
/ Jaeger MG, Schwalb B, Mackowiak SD, Velychko T, Hanzl A, Imrichova H, Brand M, Agerer B, Chorn S, Nabet B, Ferguson FM, Müller AC, Bergthaler A, Gray NS, Bradner JE, Bock C, Hnisz D, Cramer P, Winter GE. Selective Mediator dependence of cell-type-specifying transcription. Nature Genetics. 2020. Jul1;52(7):719–727. DOI: 10.1038/s41588-020-0635-0. Article ->
/ Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. eLife. 2017. 6: e31012. DOI: 10.7554/eLife.31012. Article ->
/ Schwalb B, Michel M, Zacher B, Frühauf K, Demel C, Tresch A, Gagneur J, Cramer P. TT-seq maps the human transient transcriptome. Science. 2016. 3;352(6290):1225-8. DOI: 10.1126/science.aad9841. Article ->
/ Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 2016. Jan 29;5:e12813. DOI: 10.7554/eLife.12813. Article ->
/ Gamalinda M, Ohmayer U, Jakovljevic J, Kumcuoglu B, Woolford J, Mbom B, Lin L, Woolford JL Jr. A hierarchical model for assembly of eukaryotic 60S ribosomal subunit domains. Genes Dev. 2014. Jan 15;28(2):198-210. DOI: 10.1101/gad.228825.113. Article ->
/ Schulz D, Schwalb B, Kiesel A, Baejen C, Torkler P, Gagneur J, Soeding J, Cramer P. Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis, Cell. 2013. Nov 21;155(5):1075-87. DOI: 10.1016/j.cell.2013.10.024. Article ->
/ Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA. Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Mol Cell. 2013. May 9;50(3):333-43. DOI: 10.1016/j.molcel.2013.03.023. Article ->
/ Sharma, K., Bairlein, M., Weber, C., Greff, Z., Kéri, G., Cox, J., Olsen, J.V., and Daub, H. Proteomics strategy for quantitative protein interaction profiling in cell extracts. Nat. Methods. 2009. 6, 741-744. DOI:10.1038/nmeth.1373. Article ->
/ Daub, H., Olsen, J.V., Bairlein, M., Gnad, F., Oppermann, F.S., Körner, R., Greff, Z., Kéri, G., Stemmann, O., and Mann, M. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell. 2008. 31, 438-448. DOI: 10.1016/j.molcel.2008.07.007. Article ->
/ Daub, H., Specht, K., and Ullrich, A. Strategies to overcome resistance to targeted protein kinase inhibitors. Nat. Rev. Drug Discov. 2004. 3, 1001-1010. DOI: 10.1038/nrd1579. Article ->
/ Godl, K., Wissing, J., Kurtenbach, A., Habenberger, P., Blencke, S., Gutbrod, H., Salassidis, K., Stein-Gerlach, M., Missio, A., Cotten, M., and Daub, H. An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2003. 100, 15434-15439. DOI: 10.1073/pnas.2535024100. Article ->
/ Daub, H., Weiss, F.U., Wallasch, C., and Ullrich, A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature. 1996 379, 557-560. DOI: 10.1038/379557a0. Article ->
